In a small bowl, combine yeast, sugar, and 1/4 cup warm milk. Let sit for 5-10 minutes.
In a large bowl (or your stand mixer) combine 2 and 1/2 cup flour, salt, egg, butter, yeast mixture, and milk. Adding additional flour as needed. You want just enough flour for the mixture to pull away from the bowl.
Knead the dough four 5-10 minutes, until the dough passes the windowpane test.
Place dough in an oiled bowl, cover, and let rise for about an hour (or until doubled in size).
While the dough is rising add onions, peppers, and ground beef to a skillet and cook until no longer brown. Add in seasonings and set aside to cool slightly as the dough finishes rising.
Pour dough onto a lightly floured counter cut into 8 equal pieces.
Flatten each piece into a 6" round circle, add a slice of cheese, and approximately 1/3 cup of meat mixture.
Carefully wrap the dough around the meat mixture and place seam side down onto a baking sheet.
Preheat oven to 350.
Bake for 20-25 minutes.
In a small bowl combine melted butter and garlic powder. Brush on top of bake biscuits and enjoy!