Brown ground beef over medium heat. Once beef is halfway cooked add in diced pepper, diced onion, and seasonings (salt, garlic powder, onion powder, and paprika).
Once the ground beef is fully cooked and the peppers and onions have softened add in cream cheese. Cook over medium heat and mix until well combined.
Assemble the quesadilla by layering tortilla, cheese, meat mixture, cheese, tortilla. Place quesadilla in a skillet and cook for 2-3 minutes before flipping and cooking an additional 2-3 minutes.